Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZGLHJ)

Drug Name

BAS-0338868 Drug Info

Synonyms

BAS-0338868; CHEMBL378903; N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzamide; N-(5-Phenethyl-[1,3,4]thiadiazol-2-yl)-benzamide; AC1LGHJD; BAS 00338868; Oprea1_674367; Oprea1_387539; MLS001208166; cid_821478; MolPort-001-925-654; ZINC338374; HMS2838C05; BDBM50187578; AKOS000542350; MCULE-7705926672; SMR000513539

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 821478
TTD Drug ID: DMZGLHJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proto-oncogene c-Src (SRC)	DTT	SRC	2.907	3.35	3.498	4.75

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene c-Src (SRC)	DTT	SRC	6.45E-01	-0.08	-0.58
Proto-oncogene c-Src (SRC)	DTT	SRC	2.08E-03	-0.52	-1.62

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11.