Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZHDFM)

Drug Name

6,7-dichloro-1H-indole-2,3-dione Drug Info

Synonyms

6,7-dichloro-1H-indole-2,3-dione; 18711-12-1; 6,7-Dichloroindoline-2,3-dione; 1H-Indole-2,3-dione,6,7-dichloro-; 6,7-dichloro-2,3-dihydro-1H-indole-2,3-dione; 6,7-dichlorisatin; 6,7-dichloroisatin; AC1Q3HQA; Isatin-based compound, 54; SCHEMBL1248801; CHEMBL222292; CTK4D9416; BDBM22834; DTXSID30588487; MolPort-004-304-808; XTXIILHWOQZVAQ-UHFFFAOYSA-N; STL381782; ZINC14979616; AKOS000139553; MCULE-1304306967; 1H-Indole-2,3-dione, 6,7-dichloro-; AJ-65537; KB-335070; FT-0620847; EN300-36024; Y-0718

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16786802
CAS Number: CAS 18711-12-1
TTD Drug ID: DMZHDFM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.