Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZT8UD)

Drug Name

[3H]JNJ 7777120 Drug Info

Synonyms

1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine; JNJ-7777120; 459168-41-3; JNJ7777120; JNJ 7777120; UNII-4H1AU2V37X; HUQJRYMLJBBEDO-UHFFFAOYSA-N; 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine; 4H1AU2V37X; CHEMBL129198; 1-[(5-CHLORO-1H-INDOL-2-YL)CARBONYL]-4-METHYL-PIPERAZINE; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine; (5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; (5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; METHANONE, (5-CHLORO-1H-INDOL-2-YL)(4-METHYL-1-PIPERAZINYL)-; STK175446; [3H]-JNJ7777120; [3H]-JNJ7777120

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Investigative	[1]

Cross-matching ID

PubChem CID: 4908365
CAS Number: CAS 459168-41-3
TTD Drug ID: DMZT8UD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H4 receptor (H4R)	DTT	HRH4	5.238	4.933	4.347	4.022

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Inflammation

ICD Disease Classification

1A00-CA43.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H4 receptor (H4R)	DTT	HRH4	1.32E-01	0.1	0.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1278).
2	A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13.