Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZTQD8)

Drug Name
Sirna-027 Drug Info
Indication
Disease Entry ICD 11 Status REF
Exudative age-related macular degeneration 9B78.3Z Phase 1/2 [1]
Neovascular age-related macular degeneration 9B78.3Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMZTQD8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
VEGFR1 messenger RNA (VEGFR1 mRNA) TT1VAUK VGFR1_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
VEGFR1 messenger RNA (VEGFR1 mRNA) DTT FLT1 4.802 4.95 4.597 3.17
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Exudative age-related macular degeneration
ICD Disease Classification 9B78.3Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
VEGFR1 messenger RNA (VEGFR1 mRNA) DTT FLT1 1.64E-05 0.29 0.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2011 Pipeline of Sirna Therapeutics.