Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZWGVP)

Drug Name

Saframycin A Drug Info

Synonyms

AC1MHXXG

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	TTUGSWA	G3P_HUMAN	Binder	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	DTT	GAPDH	12.082	12.019	12.258	11.809

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	DTT	GAPDH	5.24E-01	-0.21	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6.