Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZX72E)

Drug Name

1-adamantan-1-yl-3-(3-hydroxypropyl)urea Drug Info

Synonyms

CHEMBL242592; SMR000144635; 1-adamantan-1-yl-3-(3-hydroxypropyl)urea; AC1M3CD5; MLS000538598; MolPort-001-628-514; HMS2462I06; ZINC2882943; 1-(3-hydroxypropyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea; STK207014; BDBM50223385; AKOS016321670; AKOS003366277; AKOS002318484; MCULE-4878985284; N-1-adamantyl-N'-(3-hydroxypropyl)urea; 1-(1-adamantyl)-3-(3-hydroxypropyl)urea; ST50766260

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2235217
TTD Drug ID: DMZX72E

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Soluble epoxide hydrolase (EPHX2)	TT7WVHI	HYES_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	8.353	7.227	6.421	8.192

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	8.78E-01	-0.1	-0.27
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	4.40E-02	-0.18	-0.42

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26.