Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM02DNQ)

Drug Name
APC-366 Drug Info
Synonyms
APC-366; UNII-TGP1HP0WBC; TGP1HP0WBC; APC 366; 178925-65-0; apc366; N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide hydrochloride; APC-366 hydrochloride; AC1L42OQ; SCHEMBL15659721; APC-366-C; APC-366-A; APC-366-R; L-Prolinamide, N2-((1-hydroxy-2-naphthalenyl)carbonyl)-L-arginyl-, monohydrochloride; (2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[(1-hydroxynaphthalene-2-carbonyl)amino]pentanoyl]pyrrolidine-2-carboxamide hydrochloride
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
177339
CAS Number
CAS 178925-65-0
TTD Drug ID
DM02DNQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tryptase alpha/beta-1 (Tryptase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [2]
Lactoferrin DMA7QTC Solid tumour/cancer 2A00-2F9Z Approved [2]
APC-2059 DM8IB6K Inflammatory bowel disease DD72 Discontinued in Phase 2 [3]
BABIM DM8AGOE Asthma CA23 Terminated [2]
BAY-17-1998 DM7LZFQ Asthma CA23 Terminated [4]
BAY-44-3428 DM40ORU Asthma CA23 Terminated [5]
Grassystatin a DM1PWX2 Discovery agent N.A. Investigative [6]
BMS-262084 DMETNA3 Discovery agent N.A. Investigative [7]
AMG-126737 DM9H7AZ Discovery agent N.A. Investigative [8]
MOL 6131 DMSF8UC Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tryptase alpha/beta-1 (Tryptase) TTM1TDX TRYB1_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003595)
2 Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.
3 Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13.
4 Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
5 Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
6 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
7 Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33.
8 Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.