Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM03RIT)

Drug Name

Rp-5-OMe-UDPalphaB Drug Info

Synonyms

5-OMe-uridine-5'-O-(alpha-boranodiphosphate); compound 18a [PMID: 22901672]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting P2Y purinoceptor 6 (P2RY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GC021109	DMQBEYV	Alzheimer disease	8A20	Phase 1	[3]
INS 316	DMTHMEI	Lung cancer	2C25.0	Discontinued in Phase 3	[4]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[4]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[4]
RB 2	DMCEFUW	Discovery agent	N.A.	Investigative	[5]
PSB-0952	DMW19LB	Discovery agent	N.A.	Investigative	[5]
5BrUTP	DMEVRH4	Discovery agent	N.A.	Investigative	[4]
MRS2782	DMZSO4R	Discovery agent	N.A.	Investigative	[6]
MRS2578	DMKMPS6	Discovery agent	N.A.	Investigative	[7]
UDP-beta-S	DMMWHAV	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorg Med Chem. 2012 Sep 15;20(18):5483-95.
2	5-OMe-uridine-5'-O-(alpha-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y(6) receptor protects against death-receptor mediated glial apoptosis. Neurosci Lett. 2014 Aug 22;578:80-4.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.
5	Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
6	Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32.
7	Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70.
8	P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.