Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0748C)

Drug Name

Meta-Tyrosine Drug Info

Synonyms

L-m-Tyrosine; 587-33-7; 3-HYDROXY-L-PHENYLALANINE; Meta-Tyrosine; (S)-2-amino-3-(3-hydroxyphenyl)propanoic acid; m-Tyrosine; 3-tyrosine; m-L-Tyrosine; 3-Hydroxyphenylalanine; UNII-D5YF57V4QW; 3-(m-Hydroxyphenyl)alanine; L-mTyr; (2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid; L-M-TYR; D5YF57V4QW; L-Phenylalanine, 3-hydroxy-; MFCD00063059; AK-86473; L-META-TYROSINE; 3-(3-HYDROXYPHENYL)-L-ALANINE; D-3-hydroxyphenylalanine; L-PHE(3-OH)-OH; (2S)-2-azaniumyl-3-(3-hydroxyphenyl)propanoate; Tyrosine, meta-; MTY; m-Tyrosine, L-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6950578
ChEBI ID: CHEBI:44303
CAS Number: CAS 587-33-7
TTD Drug ID: DM0748C

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[2]
L-Tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[3]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[4]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[5]
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[6]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[7]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[8]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[1]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[9]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
3	Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
4	Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
5	Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
6	Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
7	Clinical pipeline report, company report or official report of Oxford BioMedica.
8	Clinical pipeline report, company report or official report of Oxford BioMedica.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).