Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM09BJ4)

Drug Name
AC-8632 Drug Info
Synonyms
5-(Tetradecyloxy)-2-furoic acid; TOFA; 54857-86-2; 5-(Tetradecyloxy)-2-furancarboxylic acid; 5-Tetradecyloxy-2-furonic acid; Rmi 14514; UNII-BI12FRY055; 2-Furancarboxylic acid, 5-(tetradecyloxy)-; MDL 14514; RMI-14514; BRN 0539681; 5-(tetradecyloxy)furan-2-carboxylic acid; BI12FRY055; CHEBI:77936; C19H32O4; 2-Furancarboxylic acid,5-(tetradecyloxy)-; AC1Q5UHU; AC1L3GNQ; 5-(tetradecyloxy)furoic acid; SCHEMBL543676; 5-tetradecyloxy-2-furoic acid; GTPL5280; CHEMBL1562779; TOFA, RMI 14514; CTK5A2675; DTXSID60203338; Acetyl-coenzyme A carboxylase inhibitor (Parkinson's disease), Accera; Acetyl-coenzyme A carboxylase inhibitor (Parkinson's disease), Neuera
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Investigative [1]
Cross-matching ID
PubChem CID
115175
ChEBI ID
CHEBI:77936
CAS Number
CAS 54857-86-2
TTD Drug ID
DM09BJ4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Acetyl-CoA carboxylase 2 (ACACB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [3]
PF-05175157 DMLQ3OK Type-2 diabetes 5A11 Phase 2 [1]
Axokine DMT5O8I Obesity 5B81 Discontinued in Phase 3 [4]
CP-640186 DMO0PS9 Discovery agent N.A. Investigative [5]
A-80040 DML20N9 Discovery agent N.A. Investigative [6]
QLT-091382 DMWOSFJ Sebaceous gland disease EM0Z Investigative [1]
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid DMWXI06 Discovery agent N.A. Investigative [7]
Soraphen A DM18IKZ Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CP-640186 DMO0PS9 Discovery agent N.A. Investigative [9]
A-80040 DML20N9 Discovery agent N.A. Investigative [6]
Haloxyfop DM5SULN Discovery agent N.A. Investigative [10]
Clodinafop DMALRU9 Discovery agent N.A. Investigative [10]
Quizalofop DM9KMEI Discovery agent N.A. Investigative [10]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetyl-CoA carboxylase 2 (ACACB) TTY84UG ACACB_HUMAN Inhibitor [1]
Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) TTYAWV0 Q9U752_PLAFA Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
2 Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000 Jun 30;288(5475):2379-81.
3 AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
4 Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
5 (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
6 Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9 Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8.
10 The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.