Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0D3HU)

Drug Name
Dihydrothieno [2,3-e]indazole derivative 2 Drug Info
Synonyms PMID25553724-Compound-WO2011077502 18
Cross-matching ID
TTD Drug ID
DM0D3HU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inhibitor of nuclear factor kappa-B kinase (IKK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydrothieno [2,3-e]indazole derivative 1 DMUJ3XK N. A. N. A. Patented [1]
Dihydrothieno [2,3-e]indazole derivative 4 DMR4LPO N. A. N. A. Patented [1]
Dihydrothieno [2,3-e]indazole derivative 3 DM85VQR N. A. N. A. Patented [1]
PMID23099093C17d DMWS7O9 Discovery agent N.A. Investigative [2]
Arsenite DMBCO4Q Discovery agent N.A. Investigative [3]
5-Bromo-6-methoxy-9H-beta-carboline DM157OQ Discovery agent N.A. Investigative [4]
MRT67307 DMYRCHG Discovery agent N.A. Investigative [5]
PS-1145 DMVUMWZ Multiple myeloma 2A83 Investigative [6]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [7]
BMS-345541 DM7D519 Arthritis FA20 Investigative [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inhibitor of nuclear factor kappa-B kinase (IKK) TTRPDBG NOUNIPROTAC Inhibitor [1]

References

1 Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34.
2 Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
3 Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
4 Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22.
5 Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
6 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7 IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001 May 25;276(21):18223-8.
8 A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9.