Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0FJIE)

Drug Name
Ontuxizumab Drug Info
Synonyms Amatuximab
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 2 [1]
Merkel cell carcinoma 2C34 Phase 2 [1]
Soft tissue sarcoma 2B57 Phase 2 [2]
Colorectal cancer 2B91.Z Phase 1 [3]
Cross-matching ID
TTD Drug ID
DM0FJIE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Endosialin (CD248)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MORAb-004 DMGK1JE Colorectal cancer 2B91.Z Phase 2 [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endosialin (CD248) TTYJWT7 CD248_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):380-8.
4 A first-in-human phase I study of MORAb-004, a monoclonal antibody to endosialin in patients with advanced solid tumors. Clin Cancer Res. 2015 Mar 15;21(6):1281-8.