Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0HXDS)

Drug Name

Pentostatin Drug Info

Synonyms

Coforin; Covidarabine; Deoxycoformycin; Nipent; Oncopent; Vidarbine; Vira A deaminase inhibitor; CL-67310465; CO-Vidarabine; Co-V; Nipent (TN); PD-81565; PD-ADI; Pentostatin (JAN/USAN/INN); (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol; (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)diazepin-8-ol; 2'-DCF; 2'-Deoxycoformycin; 2'-Dexoycoformycin

Indication

Disease Entry	ICD 11	Status	REF
Acute graft versus host disease	4B24.0	Approved	[1]
Hairy cell leukaemia	2A82.2	Approved	[2]
Leukemia		Approved	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 439693
CAS Number: CAS 53910-25-1
TTD Drug ID: DM0HXDS
ACDINA Drug ID: D01335

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[4]
Elapegademase	DMS7OU8	Adenosine deaminase defciency	4A01.1	Approved	[5]
Fludarabine	DMVRLT7	Acute myelogenous leukaemia	2A41	Approved	[3]
GSK2696273	DMP5O1U	Chronic pain	MG30	Preregistration	[6]
OTL-101	DMLMS6J	Severe combined immunodeficiency	4A01.10	Phase 3	[7]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy	DMIREUZ	Immunodeficiency	4A00-4A85	Phase 1/2	[6]
EHNA	DM014WS	Discovery agent	N.A.	Investigative	[8]
3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol	DMZT8QX	Discovery agent	N.A.	Investigative	[9]
3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol	DMAIS1D	Discovery agent	N.A.	Investigative	[9]
1-Deaza-Adenosine	DMG0VN6	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[3]

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References

1	Pentostatin FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
3	Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
4	Cladribine: from the bench to the bedside--focus on hairy cell leukemia. Expert Rev Anticancer Ther. 2004 Oct;4(5):745-57.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Clinical pipeline report, company report or official report of GlaxoSmithKline.
7	Clinical pipeline report, company report or official report of Orchard Therapeutics.
8	Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors. Biochem Pharmacol. 1977 Mar 1;26(5):359-67.
9	Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.