Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0KDTG)

Drug Name

ARC-1028 Drug Info

Synonyms

ARC-1028; CHEMBL525385; BDBM27227; ARC-1028, 22

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting cGMP-dependent protein kinase (cGK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
STAUROSPORINONE	DMU2H4K	Discovery agent	N.A.	Investigative	[2]
TENELLONE A	DM1S209	Discovery agent	N.A.	Investigative	[3]
TENELLONE B	DM9ZVJ7	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
cGMP-dependent protein kinase (cGK)	TTZC6DR	KGP1_HUMAN; KGP2_HUMAN	Inhibitor	[1]

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References

1	Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhi... J Med Chem. 2009 Jan 22;52(2):308-21.
2	Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 3(10):1959-1964 (1993).
3	Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611-3.