General Information of Drug (ID: DM0KVJC)

Drug Name
EC-145 Drug Info
Synonyms EC-0255; EC-0260
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
PubChem CID
25014653
CAS Number
CAS 742092-03-1
TTD Drug ID
DM0KVJC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [3]
Mirvetuximab soravtansine DM5S4LX Ovarian cancer 2C73 Approved [4]
EC20 DMLA1ER Ovarian cancer 2C73 Phase 3 [5]
MK-8109 DM84LO5 Ovarian cancer 2C73 Phase 3 [6]
Farletuzumab DMFLWX1 Non-small-cell lung cancer 2C25.Y Phase 3 [7]
FolateImmune DMB9ADM Renal cell carcinoma 2C90 Phase 2 [8]
Talotrexin DM1AB4L Solid tumour/cancer 2A00-2F9Z Phase 1/2 [9]
BMS-753493 DMDQO0S Solid tumour/cancer 2A00-2F9Z Phase 1/2 [10]
EC0489 DM8RD4T Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
IMGN-853 DMR8OG2 Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Folate receptor alpha (FOLR1) TTVC37M FOLR1_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT00507741) Study of Vintafolide (MK-8109, EC145) in Participants With Advanced Ovarian and Endometrial Cancers (MK-8109-007, EC-FV-02). U.S. National Institutes of Health.
2 Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 EP patent application no. 2822386, Folate receptor alpha binding ligands.
6 A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer. Drug Des Devel Ther. 2015; 9: 4989-4996.
7 Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.Gynecol Oncol.2013 Jun;129(3):452-8.
8 Responsiveness of the Effective Consumer Scale (EC-17). J Rheumatol. 2009 Sep;36(9):2087-91.
9 Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301.
10 A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31.
11 National Cancer Institute Drug Dictionary (drug id 638649).
12 Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92.