Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0P8CE)

Drug Name
BX-044 Drug Info
Synonyms Plasminogen activator inhibitor inhibitors, Berlex; ZK-4044; PAI-1 inhibitors, Berlex
Indication
Disease Entry ICD 11 Status REF
Thrombosis DB61-GB90 Terminated [1]
Cross-matching ID
TTD Drug ID
DM0P8CE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasminogen activator inhibitor (PAI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aleplasinin DMYTIP4 Alzheimer disease 8A20 Phase 1 [3]
XR-1853 DMFHR2O Thrombosis DB61-GB90 Terminated [4]
T-686 DMOGQ2L Arteriosclerosis BD40 Terminated [5]
XR-5082 DMEVSZO Thrombosis DB61-GB90 Terminated [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasminogen activator inhibitor (PAI) TT5QA2I PAI1_HUMAN; PAI2_HUMAN; IPSP_HUMAN Inhibitor [2]

References

1 Inhibition of PAI-1: a new anti-thrombotic approach. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Jun;2(1):27-42.
2 Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res. 2005;115(4):341-50.
3 CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders.
4 Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43.
5 T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6.
6 Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15.