Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0PV2Y)

Drug Name

Hippuristanol Drug Info

Synonyms

80442-78-0; SCHEMBL1374807; CHEMBL1098427; DTXSID50433627; BDBM50235738; Q10861089

Indication

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting HUMAN eukaryotic initiation factor-4A (eIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
eFT226	DMHRCQI	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
Silvestrol	DM5JKNF	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN eukaryotic initiation factor-4A (eIF4A)	TTIGYVZ	IF4A1_HUMAN; IF4A2_HUMAN; IF4A3_HUMAN	Inhibitor	[2]

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References

1	Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. Translation (Austin). 2016 Jan 4;4(1):e1137381.
2	Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol. 2011 Mar 15;81(6):713-22.
3	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem. 2020 Jun 11;63(11):5879-5955.
4	Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129.