Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0UXNF)

Drug Name

VE-821 Drug Info

Synonyms

ATR serine/threonine protein kinase inhibitors (cancer), Oxford University; ATR serine/threonine protein kinase inhibitors (cancer), Vertex Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 51000408
ChEBI ID: CHEBI:124916
CAS Number: CAS 1232410-49-9
TTD Drug ID: DM0UXNF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Serine/threonine-protein kinase ATR (FRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD6738	DM0PFNC	Small-cell lung cancer	2C25.Y	Phase 2	[3]
RP-3500	DM9FNC8	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
Camonsertib	DMOPPXY	Aggressive cancer	2A00-2F9Z	Phase 1/2	[5]
BAY1895344	DML781M	Lymphoma	2A80-2A86	Phase 1	[6]
VX-970	DMR9PCT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
M4344	DMQBO3V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
M1774	DMP8QY2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
CGK733	DM8OAN9	Discovery agent	N.A.	Investigative	[8]
AZ20	DMNQ3HV	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine/threonine-protein kinase ATR (FRP1)	TT8ZYBQ	ATR_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8042).
2	ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
3	National Cancer Institute Drug Dictionary (drug id 754022).
4	Clinical pipeline report, company report or official report of Repare Therapeutics.
5	Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nat Med. 2023 Jun;29(6):1400-1411.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	National Cancer Institute Drug Dictionary (drug name M1774).
8	Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74.
9	Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14;56(5):2125-38.