Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0YFZ6)

Drug Name

D-43787 Drug Info

Synonyms

D-43787; UNII-18SFZ71BQO; 198016-44-3; 18SFZ71BQO; CTK8E8581; DTXSID30173514; ZINC3960990; d43787; 1H-Indole-1-carboxylic acid, 2-(((2S)-2,3-dihydro-2-((((1S)-1-(methoxycarbonyl)-5-(((phenylmethoxy)carbonyl)amino)pentyl)amino)carbonyl)-1H-indol-1-yl)carbonyl)-2,3-dihydro-, 1,1-dimethylethyl ester, (2S)-; RT-012166; FT-0665439; J-012788; (2S)-2-[[(2S)-2,3-Dihydro-2-[[[(1S)-1-(methoxycarbonyl)-5-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]carbonyl]-1H-indol-1-yl]carbonyl]-2,3-dihydro-1H-Indole-1-carboxylic Acid 1,1-Dime

Indication

Disease Entry	ICD 11	Status	REF
Allergy	4A80-4A85	Terminated	[1]

Cross-matching ID

PubChem CID: 9961556
CAS Number: CAS 198016-44-3
TTD Drug ID: DM0YFZ6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Calcium signal-modulating cyclophilin ligand (CAML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alisporivir	DM83EBP	Duchenne dystrophy	8C70	Phase 3	[3]
SCY-635	DM1C9NQ	Hepatitis C virus infection	1E51.1	Phase 2	[4]
SCY-641	DMELFBU	Ocular inflammation	9C61.24	Preclinical	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium signal-modulating cyclophilin ligand (CAML)	TTATDGJ	CAMLG_HUMAN	Binder	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010545)
2	Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787. J Pharmacol Exp Ther. 2002 May;301(2):738-46.
3	DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One. 2010 Oct 27;5(10):e13687.
4	SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob Agents Chemother. 2010 Feb;54(2):660-72.
5	2011 Pipeline of SCYNEXIS.