Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM10KIW)

Drug Name

PTHr pepducins Drug Info

Synonyms

PTHr pepducins (endocrine/metabolic disorders); PTHr pepducins (endocrine/metabolic disorders), Anchor Therapeutics; Parathyroid hormone receptor-modulating pepducins (lipopeptide, endocrine/metabolic disorders), Anchor Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Endocrine disease	5B3Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DM10KIW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Parathyroid hormone receptor (PTH2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BA-058	DMPV6B2	Osteoporosis	FB83.0	Phase 3	[2]
GSK768974	DMIEXUM	Osteoporosis	FB83.0	Phase 2	[3]
NPSP-795	DM3DQXG	Osteoporosis	FB83.0	Phase 2	[1]
UNI-PH (1-34)	DM8LBUK	Osteoporosis	FB83.0	Phase 2	[4]
PTH(7-34) liposomal cream	DMRQ5YT	Alopecia	ED70	Phase 1	[5]
Semparatide	DMLK605	Osteoporosis	FB83.0	Discontinued in Phase 2	[6]
BB-PTH 1-84	DM85AJ4	Osteoporosis	FB83.0	Investigative	[1]
Hemoparatide	DMF7X31	Discovery agent	N.A.	Investigative	[7]
ZP-2307	DM8WRAU	Osteoporosis	FB83.0	Investigative	[1]
SDZ-PTS-893	DMBYSEM	Discovery agent	N.A.	Investigative	[8]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Parathyroid hormone receptor (PTH2R)	TTEPJL5	PTH2R_HUMAN	Modulator	[1]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332).
2	Emerging therapies for the treatment of osteoporosis. J Midlife Health. 2013 Jul-Sep; 4(3): 147-152.
3	Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone. 2000 Oct;27(4):471-8.
4	Parathyroid hormone for the treatment of osteoporosis: a systematic review. CMAJ. 2006 July 4; 175(1): 52-59.
5	Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure. Bone. 2008 Dec;43(6):1022-30.
6	Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):83-90.
7	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
8	Long-term therapy of ovariectomy-induced osteopenia with parathyroid hormone analog SDZ PTS 893 and bone maintenance in retired breeder rats. Bone. 1999 Nov;25(5):561-9.