Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM13HGN)

• Drug Name: 1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene Drug Info
• Synonyms: CHEMBL191195; 1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44400752
  TTD Drug ID: DM13HGN

Molecule-Related Drug Atlas

Drug(s) Targeting Presenilin 1 (PSEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[2]
R-flurbiprofen	DMFIVSR	N. A.	N. A.	Phase 2	[2]
(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone	DMREVX9	Discovery agent	N.A.	Investigative	[3]
(5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone	DMHG7MU	Discovery agent	N.A.	Investigative	[3]
Drug 311951	DMXTCJ1	Discovery agent	N.A.	Investigative	[4]
Drug 311383	DM5QUJV	Discovery agent	N.A.	Investigative	[4]
1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one	DMF9X2T	Discovery agent	N.A.	Investigative	[3]
(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone	DMJE83O	Discovery agent	N.A.	Investigative	[3]
Drug 311952	DM27ILS	Discovery agent	N.A.	Investigative	[4]
Drug 311440	DMOIFBK	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Presenilin 2 (PSEN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[2]
R-flurbiprofen	DMFIVSR	N. A.	N. A.	Phase 2	[2]
(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone	DMREVX9	Discovery agent	N.A.	Investigative	[3]
(5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone	DMHG7MU	Discovery agent	N.A.	Investigative	[3]
Drug 311951	DMXTCJ1	Discovery agent	N.A.	Investigative	[4]
Drug 311383	DM5QUJV	Discovery agent	N.A.	Investigative	[4]
1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one	DMF9X2T	Discovery agent	N.A.	Investigative	[3]
(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone	DMJE83O	Discovery agent	N.A.	Investigative	[3]
Drug 311952	DM27ILS	Discovery agent	N.A.	Investigative	[4]
Drug 311440	DMOIFBK	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Presenilin 1 (PSEN1)	TTZ3S8C	PSN1_HUMAN	Inhibitor	[1]
Presenilin 2 (PSEN2)	TTWN3F4	PSN2_HUMAN	Inhibitor	[1]

References

• [1] Aryl sulfones: a new class of gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8.
• [2] The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23.
• [3] Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6.
• [4] Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3.