Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM16KSA)

Drug Name

Phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Drug Info

Synonyms

CHEMBL566340; phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide; SCHEMBL7920067; GTPL6564; BDBM50303774

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Neuroendocrine convertase 2 (PCSK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuroendocrine convertase 1 (PCSK1)	TTED9LZ	NEC1_HUMAN	Inhibitor	[2]
Neuroendocrine convertase 2 (PCSK2)	TT46F0P	NEC2_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6564).
2	Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75.
3	Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.