General Information of Drug (ID: DM18IKZ)

Drug Name
Soraphen A Drug Info
Synonyms
122547-72-2; Soraphen A(1alpha); AC1O5R15; (1S,2S,3Z,5R,6S,11S,14S,15R,16R,17S,18S)-15,17-dihydroxy-5,6,16-trimethoxy-2,14,18-trimethyl-11-phenyl-12,19-dioxabicyclo[13.3.1]nonadec-3-en-13-one; 4,19-Dioxabicyclo(13.3.1)nonadec-12-en-3-one, 1,17-dihydroxy-10,11,18-trimethoxy-2,14,16-trimethyl-5-phenyl-, (1R-(1R*,2S*,5S*,10S*,11R*,12E,14S*,15S*,16S*,17S*,18R*))-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281897
ChEBI ID
CHEBI:9200
CAS Number
CAS 122547-72-2
TTD Drug ID
DM18IKZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [2]
PF-05175157 DMLQ3OK Type-2 diabetes 5A11 Phase 2 [3]
Axokine DMT5O8I Obesity 5B81 Discontinued in Phase 3 [4]
CP-640186 DMO0PS9 Discovery agent N.A. Investigative [5]
A-80040 DML20N9 Discovery agent N.A. Investigative [6]
AC-8632 DM09BJ4 Parkinson disease 8A00.0 Investigative [3]
QLT-091382 DMWOSFJ Sebaceous gland disease EM0Z Investigative [3]
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid DMWXI06 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetyl-CoA carboxylase 2 (ACACB) TTY84UG ACACB_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
4 Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
5 (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
6 Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.