Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1945H)

Drug Name

JTT-251 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary arterial hypertension	BB01.0	Phase 2	[1]
Type-2 diabetes	5A11	Phase 1	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Pyruvate dehydrogenase kinase (PDHK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTT-861	DM9M1K0	Chronic heart failure	BD1Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pyruvate dehydrogenase kinase (PDHK)	TT3UNDH	NOUNIPROTAC	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT03789643) Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial Hypertension (RELIEF-PAH). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT02106585) Study of Safety, Tolerability and Pharmacokinetics of Single Oral JTT-251 Doses in Healthy and Type 2 Diabetic Subjects. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Akros Pharma