General Information of Drug (ID: DM1DMR2)

Drug Name
C[RGDf-(3R)-Carboxymorpholine] Drug Info
Synonyms CHEMBL443362; c[RGDf-(3R)-Carboxymorpholine]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44123805
TTD Drug ID
DM1DMR2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Integrin alpha-V (ITGAV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Abituzumab DMTCXSG Colorectal cancer 2B91.Z Phase 2 [2]
IMGN-388 DMSYB83 Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
SB-223245 DM3JQCF N. A. N. A. Terminated [4]
C(-GRGDfL-) DMTMJAI Discovery agent N.A. Investigative [5]
SB-265123 DM8UKH7 Discovery agent N.A. Investigative [6]
C(RGDfF) DMMBESU Discovery agent N.A. Investigative [7]
Ac-Asp-Arg-Leu-Asp-Ser-OH DMYHADT Discovery agent N.A. Investigative [8]
C[-Arg-Gly-Asp-Acpca21-] DMXCUDV Discovery agent N.A. Investigative [9]
C-[-Arg-Gly-Asp-Acpca32-] DMVM7B2 Discovery agent N.A. Investigative [9]
Cyclo-[-Arg-Gly-Asp-Amp22-] DMBELJK Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-V (ITGAV) TTT1R2L ITAV_HUMAN Inhibitor [1]

References

1 Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity. Bioorg Med Chem. 2009 Feb 15;17(4):1542-9.
2 Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial. Ann Oncol. 2015 Jan;26(1):132-40.
3 Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. Cancer Res. 2010 Oct 1;70(19):7591-9.
4 Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a resten... Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6.
5 Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81.
6 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41.
7 Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17.
8 Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one sc... Bioorg Med Chem. 2007 Dec 1;15(23):7380-90.
9 Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87.
10 Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82.