Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1EB6H)

Drug Name

ZD-7349 Drug Info

Synonyms

VLA-4 antagonists, Zeneca

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JSM 6427	DM4QIOH	Macular degeneration	9B78.3	Phase 1	[3]
GW-559090	DM1FIN9	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[4]
TR-14531	DMH5SA6	Asthma	CA23	Discontinued in Phase 1	[5]
DW-908e	DMXJ54Z	Allergy	4A80-4A85	Discontinued in Phase 1	[6]
C(-GRGDfL-)	DMTMJAI	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009742)
2	Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1279-88.
3	An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci. 2008 Dec;39(4):579-85.
4	Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol. 2008 January; 83(1): 1-12.
5	US patent application no. US2010278784 (A1), Methods and compositions for treating skin conditions.
6	WO patent application no. 2008,1439,28, Methods and compositions for treating skin conditions.
7	Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81.