Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1EPMF)

Drug Name

GSK1322322 Drug Info

Synonyms

GSK-1322322

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus Peptide deformylase (Stap-coc def)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Actinonin	DMT4P89	N. A.	N. A.	Terminated	[2]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[3]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[3]
Cysteinesulfonic Acid	DMXI8FP	Discovery agent	N.A.	Investigative	[3]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[3]
HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE	DMA4SIN	Discovery agent	N.A.	Investigative	[4]
2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE	DMWMFTJ	Discovery agent	N.A.	Investigative	[4]
[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL	DM7NXMB	Discovery agent	N.A.	Investigative	[4]
VRC3375	DM1QKVL	Discovery agent	N.A.	Investigative	[5]
N-alkyl urea hydroxamic acids	DM9T0OK	Discovery agent	N.A.	Investigative	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Peptide deformylase (Stap-coc def)	TTICO5G	DEF_STAAU	Modulator	[1]

------------------------------------------------------------------------------------

References

1	Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36.
2	Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39(6):1256-62.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5	Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob Agents Chemother. 2004 Jan;48(1):250-61.
6	N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity. Antimicrob Agents Chemother. 2002 Sep;46(9):2752-64.