Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1EPZB)

• Drug Name: [des-His1,Tyr5,Glu9,D-Ala10]glucagon-NH2 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44460671
  TTD Drug ID: DM1EPZB

Molecule-Related Drug Atlas

Drug(s) Targeting Glucagon receptor (GCGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucagon recombinant	DMFLUTR	Hypoglycemia	5A41	Approved	[2]
Dasiglucagon	DM74SVE	Hypoglycemia	5A41	Approved	[3]
Retatrutide	DM8WU0Q	Obesity	5B81	Phase 3	[4]
MK-8521	DMVNAYE	Type-2 diabetes	5A11	Phase 2	[5]
LY2944876	DML6XWR	Diabetic complication	5A2Y	Phase 2	[6]
TT-401	DMRQ0SA	Type-2 diabetes	5A11	Phase 2	[5]
LGD-6972	DMPL9KG	Type-2 diabetes	5A11	Phase 2	[7]
PF-06291874	DMN94QM	Type-2 diabetes	5A11	Phase 2	[8]
LY-2409021	DMZOIP4	Type-2 diabetes	5A11	Phase 2	[9]
REMD 477	DM13OVF	Type-1 diabetes	5A10	Phase 2	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor (GCGR)	TT9O6WS	GLR_HUMAN	Inhibitor	[1]

References

• [1] Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem. 1996 Jun 21;39(13):2449-55.
• [2] Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach. Biochem Biophys Res Commun. 2007 Jun 15;357(4):865-70.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
• [4] Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity? Expert Opin Investig Drugs. 2023 May;32(5):355-359.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [7] Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31.
• [8] Clinical pipeline report, company report or official report of pfizer.
• [9] Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Diabetes Obes Metab. 2015 Apr;17(4):414-22.
• [10] Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial. Diabetes Obes Metab. 2018 May;20(5):1302-1305.