Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1GR4M)

Drug Name

Afamitresgene autoleucel Drug Info

Synonyms

afami-cel

Indication

Disease Entry	ICD 11	Status	REF
Soft tissue sarcoma	2B57	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Melanoma-associated antigen 4 (MAGEA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ADP-A2M4	DMRYH3M	Synovial sarcoma	2B5A	Phase 2	[3]
CAR-T cells targeting MAGE-A4	DMUBEX4	Lung cancer	2C25.0	Phase 1/2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanoma-associated antigen 4 (MAGEA4)	TT9EQUY	MAGA4_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT04044768) A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR? T Cells in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma. U.S.National Institutes of Health.
2	Autologous T cell therapy for MAGE-A4(+) solid cancers in HLA-A*02(+) patients: a phase 1 trial. Nat Med. 2023 Jan;29(1):104-114.
3	Clinical pipeline report, company report or official report of Adaptimmune.
4	ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer