Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1J3LE)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cellular inhibitor of apoptosis 1 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[2]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[3]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-3	DMPSWXU	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-4	DM9RZSH	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-21	DMIE0MR	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular inhibitor of apoptosis 1 (BIRC2)	TTQ5LRD	BIRC2_HUMAN	Antagonist	[1]

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References

1	Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.
2	Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
3	cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.