Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1KTOC)

Drug Name

TGX-6B4 Drug Info

Synonyms

Antiglycoprotein 1b monoclonal antibodies, CuraGen; GPIb-blocking MAb, Thromb-X; GPIb-blocking Fab fragment (thrombosis), Thromb-X

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Platelet glycoprotein Ib alpha (CD42b)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZK-001	DMDJSOH	Thrombosis	DB61-GB90	Phase 1/2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet glycoprotein Ib alpha (CD42b)	TTVB0Q9	GP1BA_HUMAN	Not Available	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015808)
2	Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates. Arterioscler Thromb Vasc Biol. 2000 May;20(5):1347-53.
3	Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb Haemost. 2014 Feb;111(2):279-89.