Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1LWMU)

Drug Name

nahuoic acid A Drug Info

Synonyms

nahuoic acid A; GTPL7022; (2E)-3-[(1R,2R,4aR,5R,7R,8R,8aS)-5,7-dihydroxy-3,4a,8-trimethyl-2-[(2E,5S,7R,8S,9S)-5,7,9-trihydroxy-8,10-dimethylundec-2-en-2-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-2-methylprop-2-enoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 71521340
TTD Drug ID: DM1LWMU

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting SET domain containing 8 (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MS2177	DMDEJBQ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[2]
MS453	DMBTPDL	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SET domain containing 8 (KMT5A)	TTGC95K	KMT5A_HUMAN	Inhibitor	[1]

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References

1	Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett. 2013 Jan 18;15(2):414-7.
2	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
3	Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem. 2016 Nov 10;59(21):9881-9889.