Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1NXFL)

• Drug Name: S-isopentyl 3-methylbutane-1-sulfinothioate Drug Info
• Synonyms: S-isopentyl 3-methylbutane-1-sulfinothioate; CHEMBL1224170; 56527-87-8

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 49865939
  TTD Drug ID: DM1NXFL

Molecule-Related Drug Atlas

Drug(s) Targeting Cysteine protease (CYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MELARSOPROL	DMGUZ0W	Trypanosomiasis	1D51-1F53	Approved	[2]
K-777	DMIFCMW	Discovery agent	N.A.	Investigative	[3]
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi)	DMDAN0K	Discovery agent	N.A.	Investigative	[4]
S-hexyl hexane-1-sulfinothioate	DMODS9A	Discovery agent	N.A.	Investigative	[1]
S-benzyl phenylmethanesulfinothioate	DMDUC2X	Discovery agent	N.A.	Investigative	[1]
S-propyl propane-1-sulfinothioate	DMFTLY9	Discovery agent	N.A.	Investigative	[1]
ALLICIN	DMSOJ6H	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cysteine protease (CYP)	TT2SUAQ	NOUNIPROTAC	Inhibitor	[1]

References

• [1] Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3.
• [2] On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide s... J Med Chem. 2009 Sep 24;52(18):5662-72.
• [3] Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
• [4] A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9.