Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1R3VC)

Drug Name

2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
S-(2-Aminophenyl)-L-cysteine S,S-dioxide	DM9Y05C	Bacterial infection	1A00-1C4Z	Preclinical	[2]
3,6,9,12,15-Pentaoxaheptadecane	DMY8IOP	Discovery agent	N.A.	Investigative	[3]
3-methoxydesaminokynurenine	DMHVIK3	Discovery agent	N.A.	Investigative	[4]
3-Hydroxyhippuric acid	DM2LBFW	Discovery agent	N.A.	Investigative	[3]
3-hydroxydesaminokynurenine	DM5T6AM	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3.
2	Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.