General Information of Drug (ID: DM205TE)

Drug Name
ISIS 10303 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DM205TE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [2]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [3]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [4]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [5]
8-Octyl-benzolactam-V9 DM4Z15M Discovery agent N.A. Investigative [6]
Go 6983 DMKVTZN Discovery agent N.A. Investigative [7]
Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P Discovery agent N.A. Investigative [8]
Dihexan-3-yl 5-(hydroxymethyl)isophthalate DM8TBQ9 Discovery agent N.A. Investigative [8]
ISIS 10310 DMT6H9S Discovery agent N.A. Investigative [1]
ISIS 17252 DMW40NK Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PKC-delta messenger RNA (PRKCD mRNA) TT7A1BO KPCD_HUMAN Not Available [1]

References

1 US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
2 Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
3 Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.
4 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
5 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
6 Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
7 Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.
8 Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81.
9 US patent application no. 6,235,723, Antisense oligonucleotide modulation of human protein kinase C-.delta. expression.