General Information of Drug (ID: DM2135Y)

Drug Name
PMID25991433-Compound-L1 Drug Info
Cross-matching ID
TTD Drug ID
DM2135Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Clinical Trial Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25991433-Compound-L2 DM58UO9 N. A. N. A. Patented [1]
PMID25991433-Compound-L3 DM3LWUR N. A. N. A. Patented [1]
PMID25991433-Compound-N3 DMLHC5V N. A. N. A. Patented [1]
Drug Name Drug ID Indication ICD 11 Highest Status REF
NKP-1339 DM5AWK1 Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [1]
PMID25991433-Compound-F2 DM37VIQ N. A. N. A. Patented [1]
7-azaindole derivative 1 DMQL5B7 N. A. N. A. Patented [1]
7-azaindole derivative 5 DMV3H98 N. A. N. A. Patented [1]
PMID25991433-Compound-P6 DMNDVC9 N. A. N. A. Patented [1]
PMID25991433-Compound-J3 DM17P3F N. A. N. A. Patented [1]
PMID25991433-Compound-P1 DMD8AX6 N. A. N. A. Patented [1]
PMID25991433-Compound-O3 DMVOWS5 N. A. N. A. Patented [1]
PMID25991433-Compound-J2 DMZSOCK N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ozagrel DMIGKA1 Xerophthalmia 5B55.Y Phase 4 [3]
Losmapimod DMIL37Z Acute coronary syndrome BA41 Phase 3 [3]
VX-702 DMKJDR6 Coronary artery disease BA80 Phase 2a [4]
VX-745 DMJAEG6 Alzheimer disease 8A20 Phase 2 [5]
Dilmapimod DMBYJ92 Acute lung injury NB32.3 Phase 2 [3]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [1]
PMID25991433-Compound-F2 DM37VIQ N. A. N. A. Patented [1]
PMID25991433-Compound-L2 DM58UO9 N. A. N. A. Patented [1]
PMID25991433-Compound-L3 DM3LWUR N. A. N. A. Patented [1]
PMID25991433-Compound-O2 DMTROIQ N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
JNK-interacting protein peptide (pepJIP) TT3ZIJL NOUNIPROTAC Inhibitor [1]
Stress-activated protein kinase 2a (p38 alpha) TTQBR95 MK14_HUMAN Inhibitor [1]
Stress-activated protein kinase JNK1 (JNK1) TT0K6EO MK08_HUMAN Inhibitor [1]

References

1 c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496).
3 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
4 Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41.
5 Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.