Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM21WOP)

Drug Name

WO2013026806C72 Drug Info

Synonyms

EHT 5372; compound 8c [PMID 25264830]; GTPL8166; BDBM50434338

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28766366-Compound-Scheme21Left	DMWTRUK	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme21Right	DMF3X40	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme14BINDY	DMBQ0RN	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme2WO2012/098065bottom	DMO4Q95	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme7WO2012/098070upper	DMGAQR5	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme9EHT1610	DMMZGC8	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme9EHT5372	DM0O18N	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme25-2	DM7OGWH	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme2WO2012/098065upper	DMVJDRI	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme7WO2012/098070bottom	DMQV6R0	N. A.	N. A.	Patented	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[4]
PMID28766366-Compound-Scheme21Left	DMWTRUK	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme21Right	DMF3X40	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme14BINDY	DMBQ0RN	N. A.	N. A.	Patented	[4]
TG003	DMP4HR2	Discovery agent	N.A.	Patented	[4]
PMID28766366-Compound-Scheme2WO2012/098065bottom	DMO4Q95	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme16DMAT	DMQ5UEA	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme7WO2012/098070upper	DMGAQR5	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme9EHT1610	DMMZGC8	N. A.	N. A.	Patented	[4]
PMID28766366-Compound-Scheme9EHT5372	DM0O18N	N. A.	N. A.	Patented	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)	TTSBVFO	DYR1A_HUMAN	Inhibitor	[2]
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)	TTYGQ8A	DYR1B_HUMAN	Inhibitor	[3]

------------------------------------------------------------------------------------

References

1	Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules. 2014 Sep 26;19(10):15411-39.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2009).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2010).
4	Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199.