Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2395E)

Drug Name
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate Drug Info
Synonyms GTPL5621; P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate; 9-[[[(2E)-3,7-dimethylocta-2,6-dienoxy]-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,5-dihydroxy-3-methylnonanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11650985
TTD Drug ID
DM2395E

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Diphosphomevalonate decarboxylase (MVD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID17888661C18 DMLPC17 Discovery agent N.A. Investigative [3]
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate DMO9BUR Discovery agent N.A. Investigative [2]
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate DMJ4SIA Discovery agent N.A. Investigative [2]
diphosphoglycolyl proline DM28NIU Discovery agent N.A. Investigative [4]
PMID17888661C19 DMRWTHA Discovery agent N.A. Investigative [3]
analog 3 (Vlattas et al., 1996) DMMKGT4 Discovery agent N.A. Investigative [5]
2,2-difluoromevalonate 5-diphosphate DMKXFDA Discovery agent N.A. Investigative [3]
6-fluoromevalonate pyrophosphate DMZ26LS Discovery agent N.A. Investigative [5]
P'-geranyl 2-fluoromevalonate 5-diphosphate DMNY187 Discovery agent N.A. Investigative [4]
2-fluoromevalonate 5-diphosphate DMEQRHY Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Diphosphomevalonate decarboxylase (MVD) TTE5J6X MVD1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5621).
2 Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.
3 Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8.
4 Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642).
6 Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta. 2006 Jul;1760(7):1080-7.