Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM24L0S)

Drug Name

ISIS 16518 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mdm2 messenger RNA (MDM2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NUTLIN-3	DM5KXFI	Discovery agent	N.A.	Investigative	[2]
NU-8231	DMEUV5R	Discovery agent	N.A.	Investigative	[3]
PLSQETFSDLWKLLPEN-NH2	DMBN4V6	Discovery agent	N.A.	Investigative	[4]
NSC-66811	DMRVMA5	Discovery agent	N.A.	Investigative	[5]
ISIS 16507	DMK69ZR	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	US patent application no. 6,238,921, Antisense oligonucleotide modulation of human mdm2 expression.
2	Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13;450(7172):1001-9.
3	Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21.
4	Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5.
5	Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening str... J Med Chem. 2006 Jun 29;49(13):3759-62.