Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM27RXS)

Drug Name

ORIN1001 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Metastatic breast cancer	2C6Y	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Endoplasmic reticulum to nucleus signaling 1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9040714, 7	DM53Z4I	N. A.	N. A.	Patented	[3]
T8361	DM86BDS	N. A.	N. A.	Patented	[4]
US8614253, 29-1	DMJKFVU	N. A.	N. A.	Patented	[5]
US8614253, 32-5	DMSQODK	N. A.	N. A.	Patented	[4]
US8614253, 29-19	DMVI83P	N. A.	N. A.	Patented	[6]
879325-11-8	DMP04Z6	N. A.	N. A.	Patented	[3]
AC1LE05K	DMPOR3G	N. A.	N. A.	Patented	[7]
US8614253, 32-4	DMRSP2M	N. A.	N. A.	Patented	[6]
BB 0223767	DM2DT6L	N. A.	N. A.	Patented	[4]
US9241942, 32-12	DM8GW54	N. A.	N. A.	Patented	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endoplasmic reticulum to nucleus signaling 1 (ERN1)	TTOJ9QL	ERN1_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT03950570) ORIN1001 in Patients With Advanced Solid Tumors and Relapsed Refractory Metastatic Breast Cancer. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Orinove.
3	IRE-1 inhibitors. US9040714.
4	IRE-1 inhibitors. US8614253.
5	IRE-1 inhibitors. US9241942.
6	IRE-1 inhibitors. US9493435.
7	IRE-1 inhibitors. US9693992.