Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM28LNV)

Drug Name

5,5-Diphenyl-2-iminohydantoin Drug Info

Synonyms

CHEMBL291784; 5,5-Diphenyl-2-iminohydantoin; SCHEMBL4237550; 2-amino-3-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one; BDBM50300229; 26975-80-4; 2-Imino-3-methyl-5,5-diphenylimidazolidin-4-one; 2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one; 1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15054176
TTD Drug ID: DM28LNV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Beta-secretase (BACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[2]
E-2609	DMTNUJ8	Alzheimer disease	8A20	Phase 3	[3]
verubecestat	DM4CGH5	Alzheimer disease	8A20	Phase 3	[4]
Lanabecestat	DMFJLB6	Alzheimer disease	8A20	Phase 3	[5]
AZD3293	DMJQHXD	Alzheimer disease	8A20	Phase 2/3	[6]
JNJ-54861911	DMGPJ5U	Alzheimer disease	8A20	Phase 2/3	[5]
R-flurbiprofen	DMFIVSR	N. A.	N. A.	Phase 2	[2]
LY2886721	DMV14LM	Alzheimer disease	8A20	Phase 2	[7]
LY3202626	DM7IFNB	Alzheimer disease	8A20	Phase 2	[5]
AZD-3839	DM72FOD	Alzheimer disease	8A20	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-secretase (BACE)	TT8JRS7	NOUNIPROTAC	Inhibitor	[1]

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References

1	Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and... J Med Chem. 2010 Feb 11;53(3):951-65.
2	The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23.
3	Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014 March; 13(3): 319-329.
4	BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	AZD3293 A novel BACE1 inhibitor: safety, tolerability, and effects on plasma and CSF A-beta peptides following single- and multiple-dose administration. Neurobiology of Aging. May 20, 2008.
7	Lessons from a BACE1 inhibitor trial: off-site but not off base.Alzheimers Dement.2014 Oct;10(5 Suppl):S411-9.
8	Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57.