Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM29BW1)

• Drug Name: SD1003 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Preclinical	[1]

• Cross-matching ID: TTD Drug ID: DM29BW1

Molecule-Related Drug Atlas

Drug(s) Targeting Cathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KGP94	DM2NZ6K	Coagulation defect	3B10.0	Clinical trial	[2]
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[3]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[3]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[3]
PMID25399719-Compound-17	DMRXKJZ	N. A.	N. A.	Patented	[4]
PMID27998201-Compound-17	DMAZVHJ	Hair loss	ED70	Patented	[3]
Phenylalanine derivative 1	DMVYP8K	Glioma	2A00.0	Patented	[3]
PMID27998201-Compound-7	DMU4QYR	Abdominal aortic aneurysm	BD50.4	Patented	[3]
PMID27998201-Compound-6	DM0LGTY	N. A.	N. A.	Patented	[3]
PMID27998201-Compound-1	DM5QH4C	Coronavirus infection	1D92	Patented	[3]

Drug(s) Targeting Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[3]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[3]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[3]
PMID27998201-Compound-17	DMAZVHJ	Hair loss	ED70	Patented	[3]
PMID27998201-Compound-11	DMTV5NU	Metastatic cancer	2D50-2E2Z	Patented	[3]
PMID27998201-Compound-2	DMMAE3C	Alzheimer disease	8A20	Patented	[3]
PMID27998201-Compound-22	DMS9QA7	Alzheimer disease	8A20	Patented	[3]
PMID27998201-Compound-13	DMZHIM8	Hepatic fibrosis	DB93.0	Patented	[3]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1	DMZ4B3W	Cerebral ischemia	8B11	Patented	[3]
PMID27998201-Compound-24	DM25BNZ	Glioma	2A00.0	Patented	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin B (CTSB)	TTF2LRI	CATB_HUMAN	Inhibitor	[1]
Cathepsin L (CTSL)	TT36ETB	CATL1_HUMAN	Inhibitor	[1]

References

• [1] Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
• [2] Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5.
• [3] Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
• [4] An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.