Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2D7Z0)

Drug Name

PPC-5650 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Acid-sensing ion channel 1 (ASIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[2]
PcTx1	DMZVJYL	Pain	MG30-MG3Z	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acid-sensing ion channel 1 (ASIC1)	TTRJYB6	ASIC1_HUMAN	Modulator	[1]

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References

1	ClinicalTrials.gov (NCT01449487) Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid. U.S. National Institutes of Health.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Challenges in analgesic drug development. Clin Pharmacol Ther. 2009 Oct;86(4):447-50.