Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2DXHO)

• Drug Name: Ro092210 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DM2DXHO

Molecule-Related Drug Atlas

Drug(s) Targeting MAPK/ERK kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[1]
LLZ16406	DMOGZLU	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting MAPK/ERK kinase kinase 2 (MAP3K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
URMC-099	DMCJXWK	Discovery agent	N.A.	Investigative	[2]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[1]
LLZ16407	DM783BP	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MAPK/ERK kinase kinase 1 (MAP3K1)	TTQBCEJ	M3K1_HUMAN	Inhibitor	[1]
MAPK/ERK kinase kinase 2 (MAP3K2)	TTK1N5G	M3K2_HUMAN	Inhibitor	[1]

References

• [1] Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
• [2] Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.