Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2IDQ9)

Drug Name

RG-7103 Drug Info

Synonyms

R-7103; RO-5024118; VPAC2 agonist (COPD), Roche

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Helodermin-preferring VIP receptor (VIPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PB1046	DM8MJ3F	Heart failure	BD10-BD13	Phase 2	[3]
PACAP-27	DMB26IK	Discovery agent	N.A.	Investigative	[4]
helodermin	DMIUABO	Discovery agent	N.A.	Investigative	[5]
PB-1120	DMX7WU9	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Helodermin-preferring VIP receptor (VIPR2)	TT4O5P0	VIPR2_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT01009424) A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease. U.S. National Institutes of Health.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)
3	Clinical pipeline report, company report or official report of PhaseBio Pharmaceuticals.
4	A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98.
5	Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52.
6	Company report (PhaseBio)