Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2J5AO)

Drug Name

R-1518 Drug Info

Synonyms

Levovirin prodrug, Roche

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase (IMPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[3]
Enteric-coated mycophenolate sodium	DMK659W	Transplant rejection	NE84	Approved	[4]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
IMS	DMFACQU	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[6]
EPB-415	DMBLSX3	Hepatitis C virus infection	1E51.1	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase (IMPDH)	TTCAQMW	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018979)
2	US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases.
3	Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
4	Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients. Clin Sci (Lond). 2004 Jul;107(1):63-8.
5	Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene. 2005 Sep 1;24(38):5888-96.
6	The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2625).