General Information of Drug (ID: DM2L3CJ)

Drug Name
MRS2693 Drug Info
Synonyms MRS-2693; MRS 2693; 5-iodo-uridine-5'-diphosphate; 5-iodo-UDP
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44415771
TTD Drug ID
DM2L3CJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting P2Y purinoceptor 6 (P2RY6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GC021109 DMQBEYV Alzheimer disease 8A20 Phase 1 [3]
INS 316 DMTHMEI Lung cancer 2C25.0 Discontinued in Phase 3 [4]
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [4]
2MeSATP DMUE0W6 Discovery agent N.A. Investigative [4]
RB 2 DMCEFUW Discovery agent N.A. Investigative [5]
PSB-0952 DMW19LB Discovery agent N.A. Investigative [5]
5BrUTP DMEVRH4 Discovery agent N.A. Investigative [4]
MRS2782 DMZSO4R Discovery agent N.A. Investigative [6]
MRS2578 DMKMPS6 Discovery agent N.A. Investigative [7]
UDP-beta-S DMMWHAV Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 6 (P2RY6) TTNVSKA P2RY6_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1747).
2 Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.
5 Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
6 Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32.
7 Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70.
8 P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.