Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2LBFW)

Drug Name

3-Hydroxyhippuric acid Drug Info

Synonyms

3-hydroxyhippuric acid; m-Hydroxyhippuric acid; 1637-75-8; (3-Hydroxybenzoylamino)acetic acid; 2-[(3-hydroxyphenyl)formamido]acetic acid; Glycine, N-(3-hydroxybenzoyl)-; UNII-17HCX0HNRT; N-m-Hydroxylbenzoylglycine; 3-Hydroxybenzoylglycine; 17HCX0HNRT; CHEMBL447627; Glycine,N-(3-hydroxybenzoyl)-; (3-hydroxybenzamido)acetic acid; CHEBI:70824; m-Hydroxyhippurate; 3-Hydroxyhippurate; AC1L9OTS; (3-hydroxybenzoyl)glycine; AC1Q75XZ; N-(3-hydroxybenzoyl)glycine; SCHEMBL600772; CTK4D1647; DTXSID30167650; MolPort-004-292-678

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 450268
ChEBI ID: CHEBI:70824
CAS Number: CAS 1637-75-8
TTD Drug ID: DM2LBFW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid	DM1R3VC	Breast cancer	2C60-2C65	Preclinical	[2]
S-(2-Aminophenyl)-L-cysteine S,S-dioxide	DM9Y05C	Bacterial infection	1A00-1C4Z	Preclinical	[3]
3,6,9,12,15-Pentaoxaheptadecane	DMY8IOP	Discovery agent	N.A.	Investigative	[1]
3-methoxydesaminokynurenine	DMHVIK3	Discovery agent	N.A.	Investigative	[4]
3-hydroxydesaminokynurenine	DM5T6AM	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kynureninase (KYNU)	TTWQM3J	KYNU_HUMAN	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3.
3	Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8.
4	Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.