Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2LU8M)

Drug Name

AP1903 Drug Info

Synonyms

Rimiducid; AP1903; 195514-63-7; UNII-H564L1W5J2; AP 1903; AP-1903; H564L1W5J2; Rimiducid [INN]; Rimiducid [USAN:INN]; CHEMBL269259; SCHEMBL10111062; DTXSID80173226; EX-A1711; AKOS030238859; CS-3162; KB-74710; HY-16046; Z-3163; 2-Piperidinecarboxylic acid, 1-(1-oxo-2-(3,4,5-trimethoxyphenyl)butyl)-, 1,2-ethanediylbis(imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene(3-(3,4-dimethoxyphenyl)propylidene)) ester, (2S-(1(R*),2R*(S*(S*(1(R*),2R*)))))-

Indication

Disease Entry	ICD 11	Status	REF
Transplant rejection	NE84	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 16135625
CAS Number: CAS 195514-63-7
TTD Drug ID: DM2LU8M

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GPI-1485	DM64ZYM	Parkinson disease	8A00.0	Phase 2	[3]
SDZ-281-240	DMPZ67G	Pruritus	EC90	Phase 2	[4]
Gpi-1046	DMD5WK4	Parkinson disease	8A00.0	Terminated	[5]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[5]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[6]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[7]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[7]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[7]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[7]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01744223) Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant. U.S. National Institutes of Health.
2	Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64.
3	Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
4	Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.