Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2MV9O)

Drug Name

DIRLOTAPIDE Drug Info

Synonyms

Dirlotapide; Slentrol; UNII-578H0RMP25; 481658-94-0; CHEMBL410414; 578H0RMP25; Dirlotapide [USAN:INN]; CP 742033; Dirlotapide (USAN/INN); Slentrol [veterinary] (TN); SCHEMBL37781; TUOSYWCFRFNJBS-BHVANESWSA-N; HY-U00070; BDBM50204367; CS-6779; CP-742033; CP-742,033; D03867; N-((1S)-2-(Benzylmethylamino)-2-oxo-1-phenylethyl)-1-methyl-5-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, 1-methyl-N-((1S)-2-(methyl(phenylmethyl)amino)-2-oxo-1-phenylethyl)-5-(((4'-(trifluoromethyl

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9917862
CAS Number: CAS 481658-94-0
TTD Drug ID: DM2MV9O

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Microsomal triglyceride transfer protein (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-201038	DMQTAGO	Familial hypercholesterolemia	5C80.00	Approved	[2]
SLx-4090	DMM3AI8	Diabetic complication	5A2Y	Phase 2	[3]
Granotapide	DMMZQ7V	Hyperlipidaemia	5C80	Phase 2	[4]
Implitapide	DMTN16K	Hyperlipidaemia	5C80	Phase 2	[5]
JNJ-16269110	DMPFG7H	Type-2 diabetes	5A11	Phase 2	[6]
KD020	DMZ416B	Kidney disease	GC2Z	Phase 1/2	[7]
GR-328713	DMUANK9	Arteriosclerosis	BD40	Discontinued in Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Microsomal triglyceride transfer protein (MTTP)	TTUS1RD	MTP_HUMAN	Inhibitor	[1]

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References

1	In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlota... Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9.
2	Dyslipidemia and cardiovascular diseases. Curr Opin Lipidol. 2009 Apr;20(2):157-8.
3	A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.
4	JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6.
5	Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan;11(1):67-70.
6	ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health.
7	Clinical pipeline report, company report or official report of Kadmon Pharmaceuticals.
8	Patent CN101237870 B.